P‐51 Drug‐induced erythema multiforme or drug‐induced pemphigus foliaceus: a case report
Identifieur interne : 000584 ( France/Analysis ); précédent : 000583; suivant : 000585P‐51 Drug‐induced erythema multiforme or drug‐induced pemphigus foliaceus: a case report
Auteurs : E. Guaguere [France] ; F. Degorce-Rubiales [France]Source :
- Veterinary Dermatology [ 0959-4493 ] ; 2004-08.
Abstract
A 5‐month‐old female Brittany spaniel was presented with peracute crusting dermatitis. The dog had been treated with cephalexin for cystitis 6 weeks earlier. Systemic signs included hyperthermia, anorexia and dehydration. Dermatological signs were characterized by crusted and exudative lesions over the face, trunk and limbs. These lesions were very painful. Clipping revealed arciform and annular patterns. The periphery of these target lesions remained indurated and ulcerated. Histopathological features of lesional skin biopsies revealed a hydropic interface dermatitis with prominent single‐cell apoptosis of keratinocytes at all levels of the epidermis and satellitosis of lymphocytes. Similar lesions were observed within the infundibular region of hair follicle outer root sheath epithelium. PCR tests (parvovirus, herpesvirus) performed from lesional biopsies were negative. Clinical and histopathological cutaneous lesions were compatible with erythema multiforme. Drug implication criteria showed the possible role of cephalexin. Symptomatic treatment (cleansing, antiseptic bathing, rehydration, antibiotics, morphine patch) was prescribed. Twenty‐four hours later, the skin was particularly painful. A pustular dermatitis was observed over the entire body. These pustules were large and contained a yellowish material. Cytology revealed nondegenerative neutrophils and acidophilic acantholytic keratinocytes. Histopathological findings included subcorneal pustules containing nondegenerative neutrophils, acantholytic keratinocytes and few eosinophils. Clinical and histopathological cutaneous lesions were compatible with pemphigus foliaceus. Prednisolone (1 mg/kg twice daily, orally), antiseptic bathings and antibiotics (marbofloxacin) were prescribed for 3 weeks. Clinical improvement was then observed. The dose of prednisolone was tapered to an alternate‐day regimen over 2 months. Cutaneous lesions completely disappeared. No relapse was observed for 4 years. The clinical succession, erythema multiforme and then pemphigus foliaceus associated with a cutaneous adverse drug reaction, is the main interest of this case. Funding: Self‐funded.
Url:
DOI: 10.1111/j.1365-3164.2004.00414_51.x
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001D80
- to stream Istex, to step Curation: 001D80
- to stream Istex, to step Checkpoint: 001F02
- to stream Main, to step Merge: 008C82
- to stream Main, to step Curation: 008A17
- to stream Main, to step Exploration: 008A17
- to stream France, to step Extraction: 000584
Links to Exploration step
ISTEX:410924E9C74E10AD6D0F9C8AE820E668DF2536FCLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">P‐51 Drug‐induced erythema multiforme or drug‐induced pemphigus foliaceus: a case report</title><author><name sortKey="Guaguere, E" sort="Guaguere, E" uniqKey="Guaguere E" first="E." last="Guaguere">E. Guaguere</name></author><author><name sortKey="Degorce Ubiales, F" sort="Degorce Ubiales, F" uniqKey="Degorce Ubiales F" first="F." last="Degorce-Rubiales">F. Degorce-Rubiales</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:410924E9C74E10AD6D0F9C8AE820E668DF2536FC</idno><date when="2004" year="2004">2004</date><idno type="doi">10.1111/j.1365-3164.2004.00414_51.x</idno><idno type="url">https://api.istex.fr/document/410924E9C74E10AD6D0F9C8AE820E668DF2536FC/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001D80</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001D80</idno><idno type="wicri:Area/Istex/Curation">001D80</idno><idno type="wicri:Area/Istex/Checkpoint">001F02</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001F02</idno><idno type="wicri:doubleKey">0959-4493:2004:Guaguere E:p:drug:induced</idno><idno type="wicri:Area/Main/Merge">008C82</idno><idno type="wicri:Area/Main/Curation">008A17</idno><idno type="wicri:Area/Main/Exploration">008A17</idno><idno type="wicri:Area/France/Extraction">000584</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">P‐51
Drug‐induced erythema multiforme or drug‐induced pemphigus foliaceus: a case report</title><author><name sortKey="Guaguere, E" sort="Guaguere, E" uniqKey="Guaguere E" first="E." last="Guaguere">E. Guaguere</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Clinique Vétérinaire Saint‐Bernard, Lomme, France; Laboratoire d’Anatomie Pathologique Vétérinaire du Sud‐ouest, Blagnac</wicri:regionArea><wicri:noRegion>Blagnac</wicri:noRegion><wicri:noRegion>Blagnac</wicri:noRegion></affiliation></author><author><name sortKey="Degorce Ubiales, F" sort="Degorce Ubiales, F" uniqKey="Degorce Ubiales F" first="F." last="Degorce-Rubiales">F. Degorce-Rubiales</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Clinique Vétérinaire Saint‐Bernard, Lomme, France; Laboratoire d’Anatomie Pathologique Vétérinaire du Sud‐ouest, Blagnac</wicri:regionArea><wicri:noRegion>Blagnac</wicri:noRegion><wicri:noRegion>Blagnac</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Veterinary Dermatology</title><title level="j" type="alt">VETERINARY DERMATOLOGY</title><idno type="ISSN">0959-4493</idno><idno type="eISSN">1365-3164</idno><imprint><biblScope unit="vol">15</biblScope><biblScope unit="page" from="57">57</biblScope><biblScope unit="page" to="57">57</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2004-08">2004-08</date></imprint><idno type="ISSN">0959-4493</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0959-4493</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A 5‐month‐old female Brittany spaniel was presented with peracute crusting dermatitis. The dog had been treated with cephalexin for cystitis 6 weeks earlier. Systemic signs included hyperthermia, anorexia and dehydration. Dermatological signs were characterized by crusted and exudative lesions over the face, trunk and limbs. These lesions were very painful. Clipping revealed arciform and annular patterns. The periphery of these target lesions remained indurated and ulcerated. Histopathological features of lesional skin biopsies revealed a hydropic interface dermatitis with prominent single‐cell apoptosis of keratinocytes at all levels of the epidermis and satellitosis of lymphocytes. Similar lesions were observed within the infundibular region of hair follicle outer root sheath epithelium. PCR tests (parvovirus, herpesvirus) performed from lesional biopsies were negative. Clinical and histopathological cutaneous lesions were compatible with erythema multiforme. Drug implication criteria showed the possible role of cephalexin. Symptomatic treatment (cleansing, antiseptic bathing, rehydration, antibiotics, morphine patch) was prescribed. Twenty‐four hours later, the skin was particularly painful. A pustular dermatitis was observed over the entire body. These pustules were large and contained a yellowish material. Cytology revealed nondegenerative neutrophils and acidophilic acantholytic keratinocytes. Histopathological findings included subcorneal pustules containing nondegenerative neutrophils, acantholytic keratinocytes and few eosinophils. Clinical and histopathological cutaneous lesions were compatible with pemphigus foliaceus. Prednisolone (1 mg/kg twice daily, orally), antiseptic bathings and antibiotics (marbofloxacin) were prescribed for 3 weeks. Clinical improvement was then observed. The dose of prednisolone was tapered to an alternate‐day regimen over 2 months. Cutaneous lesions completely disappeared. No relapse was observed for 4 years. The clinical succession, erythema multiforme and then pemphigus foliaceus associated with a cutaneous adverse drug reaction, is the main interest of this case. Funding: Self‐funded.</div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><country name="France"><noRegion><name sortKey="Guaguere, E" sort="Guaguere, E" uniqKey="Guaguere E" first="E." last="Guaguere">E. Guaguere</name></noRegion><name sortKey="Degorce Ubiales, F" sort="Degorce Ubiales, F" uniqKey="Degorce Ubiales F" first="F." last="Degorce-Rubiales">F. Degorce-Rubiales</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000584 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000584 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= France
|étape= Analysis
|type= RBID
|clé= ISTEX:410924E9C74E10AD6D0F9C8AE820E668DF2536FC
|texte= P‐51 Drug‐induced erythema multiforme or drug‐induced pemphigus foliaceus: a case report
}}
| This area was generated with Dilib version V0.6.31. |  |